How to avoid weight gain? Eat on a schedule

By MyHealthNewsDaily.com

Weight gain may caused in part by eating on an odd eating schedule, rather than only by eating too many calories, a new study in mice suggests.

Mice in the study that were fed a high-fat diet and allowed to eat whenever they wanted to, not surprisingly, gained weight. In contrast, mice that had their feeding restricted to eight hours a day were protected against obesity, despite the fact that they consumed just as many calories as the unrestricted mice.

The findings suggest that restricting meal times might be an underappreciated way to help people keep off the pounds, the researchers said.

“Every organ has a clock,” said study researcher Satchidananda Panda, of the Salk Institute for Biological Studies in La Jolla, Calif. That means there are times that our livers, intestines, muscles and other organs work at peak efficiency, and other times when they are — more or less — sleeping, Panda said.

These metabolic cycles are critical for processes such as cholesterol breakdown, and they should be turned on when we eat and turned off when we don’t, Panda said. When mice or people eat frequently throughout the day and night, it can throw off those normal metabolic cycles, he added.

Over the 18-week study, the time-restricted mice were protected from the adverse effects of their high-fat diet, and showed improvements in their metabolism compared with the unrestricted mice. They gained 28 percent less weight than unrestricted mice and suffered less liver damage.

Further work is needed to show the same thing happens in people, the researchers said. More studies should collect information on when people eat, and not just what they eat, Panda said.

Panda said there is reason to think our eating patterns have changed in recent years, as many people have greater access to food and stay up late into the night, even if just to watch TV. And when people are awake, they tend to snack, Panda said.

The study is published online today (May 17) in the journal Cell Metabolism.

Article source: http://todayhealth.today.msnbc.msn.com/_news/2012/05/17/11746549-how-to-avoid-weight-gain-eat-on-a-schedule?lite

Why it’s hard for kids to lose weight


Childhood obesity isn't just a cosmetic issue, although studies show overweight children are often isolated and bullied.

Editor’s note: This is the fourth story in CNN’s series exploring the issues surrounding childhood obesity.

(CNN) — Lyn McDonald is doing everything right.

After losing more than 80 pounds, she taught her kids how to control their portion sizes, shop at the farmers market, eat vegetables with every meal and avoid a lot of sugar.

Her efforts are working. At a time when approximately one-third of American children are overweight or obese, McDonald’s kids are at healthy weights.

So why is every day still a struggle for the blogger and mother of five?


‘Hard to be a little girl if you’re not’


School kids have easy access to snacks

“I have had to deal with teachers who hand out Skittles, candy bars, lollipops and giant frosted sugar cookies to the children in class … before 10 a.m.,” McDonald says. “I think this is setting kids up for failure and un-teaching the healthy habits I have instilled.”

The fact that doughnuts and cupcakes are given out as a reward after soccer practice or dance class is a paradoxical hurdle in the fight against childhood obesity. As doctors and parents struggle to encourage healthy behaviors, our sugar-filled, sedentary surroundings resist every step.

Think about it, says Dr. Stephen Daniels, chief pediatrician at Children’s Hospital Colorado. Every day kids are exposed to advertising about fast food instead of home-cooked meals. They’re surrounded by vending and soda machines at school. They have hundreds of channels on TV, own three video game systems and live in neighborhoods that were built without sidewalks.

“Our environment is constantly pushing kids in the wrong direction.”

Childhood obesity isn’t just a cosmetic issue, although studies have shown overweight children are often isolated and bullied by their peers.

Obese youth are more likely to suffer from cardiovascular disease, diabetes, sleep apnea, liver disease and bone and joint problems, according to the Centers for Disease Control and Prevention. Excess fat has also been linked to many types of cancer. About two-thirds of obese children grow up to be obese adults.

Gary Evans is an environmental and developmental psychologist at Cornell University. His latest study, published this year in the journal Pediatrics, analyzed the effects of stress on weight gain in children and adolescents.

Researchers know that both adults and children seek higher fat foods in response to stress. Evans and his team found that stress also damages a child’s ability for self-control, which leads to a higher body mass index as a teen.

Evans examined children who were dealing with stressful situations, such as poverty, single parenthood, housing problems and domestic violence. In the study, stress hormones hurt the brain’s pre-frontal cortex — the one responsible for our ability to plan and avoid temptations — at the cellular level.

See also: How to stop your kids from stressing

It’s kind of a quadruple whammy, Evans notes. Lower income children have less healthy food stores nearby, more junk food available because it’s cheap, fewer places to play outdoors and, as his team found out, a harder time curbing bad impulses.

“If you are born poor, your life expectancy is less,” Evans wrote in an e-mail. “Perhaps even more striking … upward mobility does not remove the ill effects of early childhood poverty on subsequent health and well-being.”

For parents trying to raise healthy kids, this is all kind of depressing.

“What we need to do as a society is work to make the healthier choice the easier choice,” says Daniels.

There has been movement in that direction. Policymakers are issuing new rules for healthier food in schools and local programs are encouraging more activity. But realistically, an environmental overhaul could take years.

There’s a danger in being too pessimistic about the influence we have on the ways our kids live, Daniels says. Research shows that children who lose weight are less likely to gain it back than teenagers or adults.

“As hard as it is to make a change at age 10, it’s that much easier than at 30 or 40.”

Twins Molly and Chris McGann, 15, are perfect examples of this. In third grade, Molly was bullied for being overweight. The McGanns started attending the Shape Down program at Children’s Hospital Colorado.

Shape Down’s instructors taught the whole family how to measure their food, cook with different colors — broccoli, red peppers, carrots — and include exercise in their daily lives. Molly dropped the extra pounds and is still at a healthy weight.

Her twin Chris hit a tough spot in middle school when undiagnosed sleep apnea caused his weight to creep up. As a teenager he is finding it more difficult to stay on track because of peer pressure. His school cafeteria, for instance, has a pizza buffet and a long line of desserts available every day.

“My friends eat the pizza and the Little Debbie cakes and they’re all as thin as rails,” he says. “It’s really hard to walk by that stuff because it looks so good. I just think I want to be healthy, I want to lose weight and I know if I eat those things it’s not going to happen.”

Daniels doesn’t talk about dieting or weight loss with his patients. He talks about getting the entire family on board to eat healthier and be more active.

“You have to understand what kinds of behaviors are leading to the problem and the changes to take,” he says. “It’s helpful to go slow. It’s about simple goals. You don’t have to get to a perfect weight in order to have the health benefits.”

For more help conquering your environment, the Mayo Clinic has suggestions on making weight loss a family affair.






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Article source: http://rss.cnn.com/~r/rss/cnn_health/~3/43uG2rvwE9w/index.html

Biking to Lose Weight

Do you want to lose weight while you bike? Bicycling is a great leisure activity, but if you are biking for weight loss you need to structure your workout differently than you would if you are just doing some casual bike riding with a friend. Learn how to set up your workout so that you get the greatest benefits out of your bicycling workout.

How Far Should I Bike to Lose Weight?

If you are biking to lose weight, distance matters less than duration. That means that you don’t necessarily have to ride the entire Tour de France to shed a few pounds. Relieved? Good. But don’t put away the odometer.

If you are new to exercise, see how far you travel when you bike for 30 minutes. Jot down the number in your workout journal and set a goal to decrease the amount of time it takes you to ride that same distance and route. As your fitness level improves you’ll be able to travel further in less time and you’ll burn more calories in the process.

As you get comfortable spending more time in the saddle, you should begin to schedule longer rides during the week. If you are biking for weight loss three days per week, make one ride a short workout (30 minutes), make one ride a moderate duration (45 minutes) and set a goal to ride one long tour (60-120 minutes) each week.

How Fast Should I Bike to Lose Weight?

Again, the answer depends on a number of factors. Exercise intensity matters more than speed. The type of bike you ride and the trail you choose will affect both intensity and speed. For example, if you are riding muddy, off-road trails on a heavy mountain bike at 12 miles per hour, you’ll probably be working very hard. But if you ride that same pace on a sleek road bike on a smooth descent, it probably means you are barely pedaling.

Your best bet? Get a heart rate monitor. That way you’ll get an exact measurement of how hard you are working. Aim to work at 70-75% of your maximum heart rate for most rides. If you don’t want to invest the money in a monitor, used a perceived exertion scale instead. On a scale of 1-10, you should feel like you are working at a level 7. You should be breathing deeply, but not exhausted or out of breathe.

Where Should I Bike for Weight Loss?

The course you choose may have the biggest impact on the number of calories you burn, because it will affect both duration and intensity. For best results, you want to choose a course that allows you to pedal consistently without taking too many breaks at stoplights or intersections. These short breaks cause your heart rate to drop, take up too much workout time, and decrease the calorie burning potential of your ride.

Many cities have dedicated continuous bike trails. Especially when you are first starting out, opt for these safe routes rather than riding in the road. If you don’t have access to a bike path, it may be worth your time to drive to a location where a long stretch of quiet road is available.

Go to page 2 to get a list of essential equipment and biking tips

Article source: http://weightloss.about.com/od/exercis1/a/Biking-To-Lose-Weight.htm

Beta blockers: Do they cause weight gain?

Sheldon Sheps, M.D.


Dr. Sheldon Sheps, emeritus professor of medicine and former chair of the Division of Nephrology and Hypertension in the Department of Medicine at Mayo Clinic, has been with Mayo Clinic since 1960.

Dr. Sheps, a Winnipeg, Manitoba, native, is board certified in internal medicine and specializes in hypertension and peripheral vascular diseases. He developed a multidisciplinary approach with specially trained nurses, dietitians, technicians and educators to help form a team approach to the treatment of patients with abnormal blood pressure.

“I have always believed in involving the patient and family in their health care,” Dr. Sheps says. “I have asked for their understanding of the illness and issues and for participation in decisions. The Web is a natural extension of that, and now many more people can be informed.”

Dr. Sheps chaired the sixth working group, and he participated in the fourth, fifth and seventh groups that developed the then-latest guidelines for hypertension under the auspices of the National Heart, Lung, and Blood Institute (NHLBI). He helped write the latest American Heart Association (AHA) report on blood pressure measurement. He chaired an AHA group that produced an online accreditation for blood pressure measurement for health professionals.

Dr. Sheps has co-authored books, newsletters, CD-ROMs and other Mayo Clinic health information material. He joined Mayo Clinic’s Web team in 1998. He was medical editor-in-chief of both editions of the “Mayo Clinic on High Blood Pressure” book; the last edition was published in 2003. He was also medical editor-in-chief of “Mayo Clinic 5 Steps to Controlling High Blood Pressure,” published in 2008.

In addition, Dr. Sheps was section editor for each of the first three editions of “Hypertension Primer” for the American Heart Association.

Dr. Sheps was also chairman of the Science Base Subcommittee and the National High Blood Pressure Education Program, and he was a consultant to the Hypertension Initiative of the World Health Organization. In 1997, he was honored with the Individual Achievement Award on the 25th anniversary of the National High Blood Pressure Education Program of NHLBI. In 2009, he was honored as a Distinguished Mayo Alumnus.

Article source: http://www.mayoclinic.com/health/beta-blockers/AN01409/rss=1

New weight loss drug a step closer to approval

Advisers to government health regulators have recommended that that they approve sales of what would be the first new prescription weight-loss drug in the U.S. in more than a decade, despite concerns over cardiac risks.

A panel of expert advisers to the Food and Drug Administration voted 18-4 to recommend approval of lorcaserin, developed by Arena Pharmaceuticals Inc. They concluded that its benefits “outweigh the potential risks when used long term” in overweight and obese people. One panel member abstained from voting.

Lorcaserin is one of three experimental weight-loss drugs whose developers have been trying for a second time to get approved, after the FDA shot them all down in 2010 or early 2011.

Copyright 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

Article source: http://www.msnbc.msn.com/id/47377790/ns/health-diet_and_nutrition/

Study: Men lost weight on testosterone therapy

(CBS News) In a new study, German researchers took a group of overweight men and restored their normal testosterone levels. The group lost weight, lowered their blood pressure, and improved their cholesterol.

The study looked at 115 obese men aged between 38-83 years with low testosterone levels, the BBC reports. Subjects were injected with the hormone every 12 weeks to increase levels. The research was paid for by Bayer Pharma, a manufacturer of testosterone replacement therapy. The study found no increased risk of prostate cancer, a side effect found in other studies. The findings were announced at the European Congress on Obesity.

Testosterone replacement therapy prescriptions have doubled over the last six years, according to the International Journal of Clinical Practice.

As prescriptions skyrocket, Dr. Harry Fisch, a urologist at New York’s Weill-Cornell Medical Center, reminds us that testosterone should never go below normal levels in a man’s lifetime. Fisch said Wednesday on “CBS This Morning,” “A lot of people think that testosterone levels as you get older go below normal levels. That’s not true.”

Fisch, author of “The Male Biological Clock,” said he can tell in a second when someone comes into his office if they have low testosterone. How? He looks at the size of belly.

“The bigger the belly the lower the testosterone,” Fisch said.

For more on the study and why Fisch doesn’t tell his patients to lose weight and exercise, watch the video in the player above.

Article source: http://feeds.cbsnews.com/~r/CBSNewsHealth/~3/1_h7zt38pDg/

Well: Weight Loss in a Pill: No Lemonade From Lemons

Right after residency, I took a summer job in a family practice in a beach town on Long Island, covering Fridays and weekends for the regular doctors. The setting was quite different from my training in an urban hospital. It was a bit of a culture shock to go from a world of critically ill hospitalized patients to an outpatient suburban setting where most weekend appointments were for sore throats, rashes and sprained ankles. But I quickly became a pro at Lyme disease identification.

Danielle Ofri, M.D.Joon Park Danielle Ofri, M.D.

One day, a woman in her early 40s came for an appointment. She asked me to prescribe fen-phen, a weight-loss pill that combined the drugs fenfluramine and phentermine and was being heavily marketed at the time.

I remember gazing at her from across the desk, thinking that she certainly didn’t look overweight, and asked her why she wanted weight-loss pills.

She grasped the skin around her stomach and said ruefully, “I’ve been trying to get rid of these extra pounds after having kids.”

I leaned over to see what she was holding in her grip. It looked like a normal amount of stomach to me.

Having just spent the past three years taking care of critically ill hospital patients who were dealing with heart attacks, septic shock, pneumonia and bleeding ulcers, I had a hard time seeing a few extra pounds as a medical issue. I was also a little leery of the whole idea of weight-loss pills, which seemed like a Band-Aid approach to what was usually a lifetime pattern of poor eating habits and inactivity.

I started to explain my concerns, noting that every medication has side effects. But before I could even get to any discussion about diet and exercise, she cut me off.

“I’ve taken fen-phen before,” she said, her voice more harsh now. “I just need a prescription from you, not a lecture.”

I was taken aback by the vociferousness of her response. I scanned her chart to see if she’d been heavier in the past. She hadn’t. In fact, she was quite healthy, with no major medical problems. I wondered if she might have an eating disorder that might alter her perception of her weight.

But we never got that far. When I reiterated my hesitations about prescribing pills for weight loss, she grew angry and stormed out in a huff.

A month later, The New England Journal of Medicine published an article linking fen-phen to heart valve abnormalities. Shortly after, the medication was pulled from the market. I wanted to feel vindicated, but I knew that during my tense exchange with my patient I hadn’t had any clinical premonitions about the drugs’ dangers, just a sense that she didn’t really need weight-loss pills.

This encounter came to mind recently when I read an essay called “Lemons for Obesity” in Annals of Internal Medicine. The author, Dr. Michael S. Lauer, was one of only two members of a 22-member Food and Drug Administration panel who earlier this year voted against approval of the new weight-loss drug Qnexa, a combination of phentermine and topiramate, an epilepsy drug with an unexpectedly salubrious side effect of weight loss.

Final approval of the drug has been delayed, but in the essay, Dr. Lauer gives a brief history of Qnexa’s approval process, including concerns of cardiovascular side effects and possible risks of cleft lip and cleft palate in babies born to mothers taking the drug. Then he makes an interesting analogy to the used-car market, citing the 1970 paper “The Market for Lemons” that eventually won a Nobel in economic science for its author, George Akerlof.

Lemons are harder to sell than quality products, so sellers do more promotion and offer steeper discounts, Dr. Akerlof had argued. In addition, used-car buyers (like patients) know much less about the product than used-car sellers (and pharmaceutical companies). Lay people rarely have much success when looking under the hoods of either cars or medicines. This combination of “information asymmetry” and aggressive marketing can allow lemons to dominate the market.

Dr. Lauer lists the impressive number of lemons for treating obesity. Fen-phen, ephedra, sibutramine and phenylpropanolamine all had to be pulled from the market for safety concerns. A drug popular in Europe, rimonabant, was denied approval in the United States because of side effects. The lone prescription drug currently available in America for weight loss, orlistat, offers only minor weight loss with the trade-off of major stomach problems in the form of oily, greasy stools.

The weight-loss field is strewn with lemons, more so than other areas of medicine, Dr. Lauer argues. Because of the enormous potential market for these drugs — two-thirds of American adults are overweight or obese — pharmaceutical companies rush new drugs to market after conducting only small clinical trials. The F.D.A. and doctors are complicit in the process, Dr. Lauer says, leaving the population at large to act essentially as guinea pigs.

Dr. Lauer cites another intriguing paper from the 1970s, by Amos Tversky and Daniel Kahneman, that highlights our biases when interpreting data, especially from small studies. There is an “illusion of validity” for any random data point, a seductive sense that is colored by what we hope will be true. Mountains of pharmaceutical claims are often made from mere molehills of data.

In the decades since my encounter with the patient who demanded fen-phen, I’ve become a lot less smug about the problem of obesity. I appreciate that there are factors at play beyond diet and exercise, but the “lemon lesson” has stayed with me. It’s hard to know at the outset which new drugs are lemons and which will become game-changers. But any drug that arrives on the scene with heavy promotion and only modest benefits deserves the same circumspect attitude as that too-good-to-be-true used car.


Danielle Ofri is the author of three books, including “Medicine in Translation: Journeys With My Patients.” She is an associate professor of medicine at New York University School of Medicine and editor in chief of the Bellevue Literary Review.

Article source: http://feeds.nytimes.com/click.phdo?i=d35451d785ef78f7d320c79d8a47e9f1